γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis
نویسندگان
چکیده
منابع مشابه
Gene expression by inflammatory neutrophils: stimulation of interleukin-1 beta production by rheumatoid synovial fluid.
The neutrophl has been thought of as a terminally differentiated cell with little or no capacity or requirement for de novo protein synthesis. It has recently been demonstrated that neutrophils are biosynthetically active and that the biosynthesis of some cellular components is essential to maintain the neutrophil in an active state [I]. It has also been shown that neutrophls can synthesise and...
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Ex vivo cytokine production by circulating lymphocytes and monocytes is reduced in patients with infectious or noninfectious systemic inflammatory response syndrome. Very few studies have addressed the reactivity of polymorphonuclear cells (PMN). To analyze further the relative contribution of systemic inflammatory response syndrome alone or in combination with infection we studied the interleu...
متن کاملPalladium attenuates the pro-inflammatory interactions of C5a, interleukin-8 and pneumolysin with human neutrophils.
The primary objective of this study was to investigate the effects of cobalt (Co(2 +)), palladium (Pd(2 +)), platinum (Pt(4 +)) and vanadium (V(2 +), V(3 +), V(4 +) and V(5 +)) on the ability of the neutrophil chemoattractants C5a and IL-8, as well as the pneumococcal toxin, pneumolysin, to activate human neutrophils in vitro. Neutrophil activation was determined according to the magnitude of t...
متن کاملInterleukin-1 expression by neutrophils in rheumatoid arthritis.
OBJECTIVE To determine if neutrophils from blood and synovial fluid of patients with rheumatoid arthritis and other joint arthropathies express interleukin-1 beta mRNA. METHODS RNA was isolated from neutrophils from patient and control blood, and synovial fluid of patients, probed in northern blots, and quantified by densitometry. It was also isolated and analysed from control blood neutrophi...
متن کاملInterleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis
Ectopic lymphoid-like structures (ELSs) reminiscent of secondary lymphoid organs often develop at sites of chronic inflammation where they contribute to immune-mediated pathology. Through evaluation of synovial tissues from rheumatoid arthritis (RA) patients, we now show that low interleukin-27 (IL-27) expression corresponds with an increased incidence of ELS and gene signatures associated with...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-25988-3